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IS Clinical

Advanced clinical skincare powered by science and botanical innovation.

iS Clinical is a professional skincare brand combining pharmaceutical-grade science, botanical ingredients, and advanced formulations to improve overall skin health and appearance. Founded by biochemist Bryan Johns, the brand develops clinically validated products for concerns including aging, blemishes, uneven tone, and texture, and is trusted by skincare professionals and consumers worldwide.

iS Clinical Retinol+ Emulsion 1.0 bottle, a maximum-strength encapsulated retinol treatment

Texture of iS Clinical Retinol+ Emulsion 1.0, a keratolytic anti-aging emulsion

iS CLINICAL®

Retinol+ Emulsion 1.0

$108.00 ~~$144.00~~ 25% Off

iS Clinical Cleansing Complex bottle, a lightweight gel cleanser with white willow bark and sugarcane extract

iS Clinical Cleansing Complex bottle on a blue gradient background

iS CLINICAL®

Cleansing Complex - 2.0 fl oz

$20.25 ~~$27.00~~ 25% Off

iS Clinical Warming Honey Cleanser tube, 4.0 fl oz, with honey, royal jelly, and papaya enzymes

iS Clinical Warming Honey Cleanser tube with golden honey texture dripping down a pedestal against a sky background

iS CLINICAL®

Warming Honey Cleanser 4.0 fl oz

$39.00 ~~$52.00~~ 25% Off

iS Clinical Copper Firming Mist bottle, 2.5 fl oz / 75 ml, a hydrating antioxidant face mist with Copper PCA

iS Clinical Copper Firming Mist bottle on a blue gradient background

iS CLINICAL®

Copper Firming Mist 2.5 fl oz / 75 ml

$33.75 ~~$45.00~~ 25% Off

iS Clinical Active Serum dropper bottle, a flagship exfoliating treatment with sugar cane, bilberry, and willow bark extracts

iS Clinical Active Serum infographic: improves pores and skin texture, paraben and hydroquinone-free, improves acne-prone skin

iS CLINICAL®

Active Serum - 1.0 oz

$116.25 ~~$155.00~~ 25% Off

iS Clinical Eclipse SPF 50+ PerfecTint Beige bottle, 3.5 oz / 100 g, an ultra sheer tinted mineral sunscreen

iS Clinical Eclipse SPF 50+ PerfecTint Beige bottle on a blue gradient background

iS CLINICAL®

Eclipse SPF 50+ - PerfecTint Beige 3.5 oz / 100 g

$40.50 ~~$54.00~~ 25% Off

iS Clinical Moisturizing Complex bottle, 1.7 oz / 50 g, with hyaluronic acid and vitamin C

Texture of iS Clinical Moisturizing Complex, a lightweight everyday moisturizer

iS CLINICAL®

Moisturizing Complex 1.7oz / 50 g

$79.50 ~~$106.00~~ 25% Off

iS Clinical GeneXC Serum dropper bottle with 20% vitamin C and Extremozyme technology

Texture of iS Clinical GeneXC Serum, an antioxidant vitamin C treatment

iS CLINICAL®

GeneXC Serum 0.5 fl oz

$85.50 ~~$114.00~~ 25% Off

iS Clinical Poly-Vitamin Serum pump bottle, 1 fl oz / 30 ml, a multivitamin hydrating serum

Texture of iS Clinical Poly-Vitamin Serum, a lightweight hydrating gel-serum

iS CLINICAL®

Poly-Vitamin Serum 1 fl oz / 30 ml

$93.75 ~~$125.00~~ 25% Off

iS Clinical Super Serum Advance+ dropper bottle, 1 fl oz / 30 ml, with 15% L-ascorbic acid and copper tripeptides

Texture of iS Clinical Super Serum Advance+, a lightweight antioxidant serum

iS CLINICAL®

Super Serum Advance+ 1 fl oz / 30 ml

$132.75 ~~$177.00~~ 25% Off

iS Clinical Youth Intensive Crème jar, an anti-aging moisturizer with hyaluronic acid and vitamin C

Texture of iS Clinical Youth Intensive Crème, a firming and hydrating moisturizer

iS CLINICAL®

Youth Intensive Crème 1.7 oz / 50g

$192.00 ~~$256.00~~ 25% Off

iS Clinical Youth Body Serum travel-size spray bottle, 0.5 fl oz / 15 ml, a hydrating body mist with hyaluronic acid

iS CLINICAL®

Youth Body Serum 0.5 fl. oz. / 15 ml

$21.75 ~~$29.00~~ 25% Off

iS Clinical NeckPerfect Complex bottle, 1.7 oz / 50g, a firming and lifting neck and décolleté treatment

Texture of iS Clinical NeckPerfect Complex, a resurfacing neck and décolleté cream

iS CLINICAL®

NeckPerfect Complex 1.7 oz. / 50g

$90.00 ~~$120.00~~ 25% Off

iS Clinical Hydra-Intensive Cooling Masque jar, 4 oz / 120g, with hyaluronic acid and centella asiatica

Texture of iS Clinical Hydra-Intensive Cooling Masque, a soothing hydrating gel masque

iS CLINICAL®

Hydra-Intensive Cooling Masque 4 oz. / 120g

$78.75 ~~$105.00~~ 25% Off

iS Clinical Eye Complex bottle, 0.5 oz / 15g, an under-eye treatment with hyaluronic acid and vitamin C

Texture of iS Clinical Eye Complex, a brightening and de-puffing eye treatment

iS CLINICAL®

Eye Complex 0.5 oz / 15g

$73.50 ~~$98.00~~ 25% Off

iS Clinical Active Serum dropper bottle, a flagship exfoliating treatment with sugar cane, bilberry, and willow bark extracts

iS Clinical Active Serum infographic: improves pores and skin texture, paraben and hydroquinone-free, improves acne-prone skin

iS CLINICAL®

Active Serum - 0.5 oz

$72.00 ~~$96.00~~ 25% Off

iS Clinical Lip Polish jar, 0.5 oz / 15 g, exfoliating lip scrub with shea butter and vitamin C

Swatch of iS Clinical Lip Polish scrub texture showing its rich, buttery consistency

iS CLINICAL®

Lip Polish 0.5 oz / 15 g

$30.00 ~~$40.00~~ 25% Off

iS Clinical PerfecTint Powder SPF 40 bottle, a brush-on mineral sunscreen with zinc oxide

Swatch of iS Clinical PerfecTint Powder SPF 40 in a light shade

iS CLINICAL®

PerfecTint Powder SPF 40

$61.50 ~~$82.00~~ 25% Off

iS Clinical Poly-Vitamin Serum dropper bottle, 0.5 fl oz / 15 ml, a multivitamin hydrating serum

Texture of iS Clinical Poly-Vitamin Serum, a lightweight hydrating gel-serum

iS CLINICAL®

Poly-Vitamin Serum 0.5 fl oz / 15 ml

$58.50 ~~$78.00~~ 25% Off

iS Clinical Tri-Active Exfoliating Masque tube, 4 oz / 120 g, with papaya enzymes and salicylic acid

Texture of iS Clinical Tri-Active Exfoliating Masque, a physical and biochemical exfoliating gel

iS CLINICAL®

Tri-Active Exfoliating Masque 4 oz / 120 g

$78.00 ~~$104.00~~ 25% Off

iS Clinical Extreme Protect SPF 40 bottle, a broad spectrum mineral sunscreen creme with zinc oxide and titanium dioxide

Texture of iS Clinical Extreme Protect SPF 40 in the Translucent shade

iS CLINICAL®

Extreme Protect SPF 40

$69.00 ~~$92.00~~ 25% Off

iS Clinical Extreme Protect SPF 30 bottle, 1.7 oz / 50 g, a broad spectrum sunscreen creme

Texture of iS Clinical Extreme Protect SPF 30 sunscreen creme

iS CLINICAL®

Extreme Protect SPF 30 1.7 oz / 50 g

$39.75 ~~$53.00~~ 25% Off

iS Clinical Hydra-Cool Serum dropper bottle, 0.5 fl oz / 15 mL, a hydrating and cooling hyaluronic acid serum

iS Clinical Hydra-Cool Serum pump bottle

iS CLINICAL®

Hydra-Cool Serum 0.5 fl oz / 15 mL

$52.50 ~~$70.00~~ 25% Off

iS Clinical Youth Serum dropper bottle, 1 fl oz / 30 mL, with growth factors and Extremozyme technology

Texture of iS Clinical Youth Serum, a firming anti-aging serum

iS CLINICAL®

Youth Serum 1 fl oz / 30 mL

$130.50 ~~$174.00~~ 25% Off

iS Clinical Youth Lip Elixir tube, 0.12 oz / 3.5 g, a hydrating lip treatment with hyaluronic acid

iS Clinical Youth Lip Elixir tube next to its retail packaging box

iS CLINICAL®

Youth Lip Elixir 0.12oz / 3.5g

$47.25 ~~$63.00~~ 25% Off

iS Clinical Youth Intensive Crème jar, an anti-aging moisturizer with hyaluronic acid and vitamin C

Texture of iS Clinical Youth Intensive Crème, a firming and hydrating moisturizer

iS CLINICAL®

Youth Intensive Crème 3.5 oz / 100g

$315.00 ~~$420.00~~ 25% Off

iS Clinical Youth Complex bottle, 1 oz / 30g, an anti-aging firming treatment with hyaluronic acid

Texture of iS Clinical Youth Complex, a firming and wrinkle-reducing treatment

iS CLINICAL®

Youth Complex 1 oz / 30g

$129.00 ~~$172.00~~ 25% Off

iS Clinical Youth Body Serum spray bottle, 6.7 fl oz / 200 ml, a hydrating body mist with hyaluronic acid

iS Clinical Youth Body Serum bottle on a blue gradient background

iS CLINICAL®

Youth Body Serum 6.7 fl oz / 200 ml

$97.50 ~~$130.00~~ 25% Off

iS Clinical Sheald Recovery Balm tube, 2 oz / 60g, a barrier repair balm with ceramides and hyaluronic acid

Texture of iS Clinical Sheald Recovery Balm, a moisture-rich barrier repair balm

iS CLINICAL®

Sheald Recovery Balm 2 oz / 60g

$66.75 ~~$89.00~~ 25% Off

iS Clinical GeneXC Serum dropper bottle with 20% vitamin C and Extremozyme technology

Texture of iS Clinical GeneXC Serum, an antioxidant vitamin C treatment

iS CLINICAL®

GeneXC Serum 1 fl oz

$138.75 ~~$185.00~~ 25% Off

iS Clinical GeneXC Firming Eye Gel with cooling metal applicator tip, 0.5 oz / 15g

iS Clinical GeneXC Firming Eye Gel infographic: Smoothing with low molecular weight hyaluronic acid and sodium hyaluronate, Firming with Palmitoyl Tripeptide-5, and Brightening with 2x Vitamin C

iS CLINICAL®

GeneXC Firming Eye Gel 0.5 oz / 15g

$97.50 ~~$130.00~~ 25% Off

iS Clinical Firming Complex bottle, 1.7 oz / 50 g, an anti-aging neck and décolleté treatment

Texture of iS Clinical Firming Complex, a smoothing and tightening treatment

iS CLINICAL®

Firming Complex 1.7 oz / 50 g

$111.00 ~~$148.00~~ 25% Off

iS Clinical C Eye Serum Advance+ dropper bottle, 0.5 oz / 15g, with 7.5% vitamin C and copper tripeptide growth factor

Texture of iS Clinical C Eye Serum Advance+, a brightening vitamin C eye treatment

iS CLINICAL®

C Eye Serum Advance+ 0.5 oz / 15g

$56.25 ~~$75.00~~ 25% Off

iS Clinical Brightening Serum bottle, a hydroquinone-free serum with alpha-arbutin and Norwegian kelp extract

Texture of iS Clinical Brightening Serum, an exfoliating and skin-tone evening treatment

iS CLINICAL®

Brightening Serum 1 fl oz / 30 ml

$114.00 ~~$152.00~~ 25% Off

iS Clinical Brightening Serum bottle, a hydroquinone-free serum with alpha-arbutin and Norwegian kelp extract

Texture of iS Clinical Brightening Serum, an exfoliating and skin-tone evening treatment

iS CLINICAL®

Brightening Serum 0.5 fl oz / 15ml

$67.50 ~~$90.00~~ 25% Off

iS Clinical Brightening Complex bottle, 1 oz, a hydroquinone-free treatment with alpha-arbutin and hyaluronic acid

Texture of iS Clinical Brightening Complex, an exfoliating and skin-tone evening treatment

iS CLINICAL®

Brightening Complex 1 oz

$124.50 ~~$166.00~~ 25% Off

iS Clinical Body Complex bottle, 6 oz, an antioxidant body lotion with hyaluronic acid and retinol

Texture of iS Clinical Body Complex, a hydrating and firming body treatment

iS CLINICAL®

Body Complex 6 oz

$59.25 ~~$79.00~~ 25% Off

iS Clinical Cleansing Complex Polish tube, 4.0 oz, a physical and biochemical exfoliating cleanser with salicylic acid

iS Clinical Cleansing Complex Polish texture infographic: deeply cleanses without drying skin, gently resurfaces smooths and hydrates skin, excellent for oily and blemish-prone skin

iS CLINICAL®

Cleansing Complex Polish 4.0 oz

$39.00 ~~$52.00~~ 25% Off